Katharios-Lanwermeyer, S., Zarrella, T. M., Godsil, M., Severin, S., Casiano, A. E., Tai, C-H., & Khare, A. (2026) A quorum sensing molecule from Pseudomonas aeruginosa induces defense multicellularity in a co-infecting pathogen. PNAS. doi: https://doi.org/10.1073/pnas.2513122123 *Preprint (2025) on bioRxiv. doi: https://doi.org/10.1101/2025.05.02.651457
Zarrella, T. M., Gao, J., Forrest, N., Crosbourne, E., Cui, K., & Bai, G. (2025) Cyclic di-AMP affects cell membrane integrity of Streptococcus pneumoniae. Molecular Microbiology. doi: https://doi.org/10.1111/mmi.70003
Warrell, D. L.^, Zarrella, T. M.^#, Machalek, C., & Khare, A.# (2024) Interspecies surfactants serve as public goods enabling surface motility in Pseudomonas aeruginosa. Journal of Bacteriology. doi: https://doi.org/10.1128/jb.00281-24 ^equal contribution #co-corresponding authors *Preprint (2024) on bioRxiv. doi: 10.1101/2024.01.03.573969
Zarrella, T. M., & Khare, A. (2022) Systematic identification of molecular mediators of interspecies sensing in a community of two frequently coinfecting bacterial pathogens. PLOS Biology. doi: 10.1371/journal.pbio.3001679 *June 2022 PLOS Biology Issue Cover Image *Preprint (2021) on biorXiv doi: https://doi.org/10.1101/2021.10.24.465352. Zarrella, T. M., Yang, J., Metzger, D. W., & Bai, G. (2020) Bacterial second messenger cyclic di-AMP modulates the competence state in Streptococcus pneumoniae. Journal of Bacteriology. doi: 10.1128/JB.00691-19. Zarrella, T. M., Metzger, D. W., & Bai, G. (2018) Stress suppressor screening leads to detection of regulation of cyclic di-AMP homeostasis by a Trk-family effector protein in Streptococcus pneumoniae. Journal of Bacteriology. doi: 10.1128/JB.00045-18. *Featured in a Commentary; doi: 10.1128/JB.00166-18. Holland, K. M., Rosa, S.J., Kristjansdottir, K., Wolfgeher, D., Franz, B. J., Zarrella, T. M., Kumar, S., Sunagar, R., Singh, A., Bakshi, C. S., Namjoshi, P., Barry, E. M., Sellati, T. J., Kron, S. J., Gosselin, E. J., Reed, D. S., & Hazlett, K. R. O. (2017) Differential growth of Francisella tularensis, which alters expression of virulence factors, dominant antigens, and surface-carbohydrate synthases, governs the apparent virulence of Ft SchuS4 to immunized animals. Frontiers in Microbiology, 8:1158.
Bai, Y., Yang, J., Zarrella, T. M., Zhang, Y., Metzger, D. W., & Bai, G. (2014) Cyclic di-AMP impairs potassium uptake mediated by a cyclic di-AMP binding protein in Streptococcus pneumoniae. Journal of Bacteriology, 196(3), 614-623. Zarrella, T. M., Singh, A., Bitsaktsis, C., Rahman, T., Sahay, B., Feustel, P. J., Gosselin, E. J., Sellati, T. S., & Hazlett, K. R. O. (2011) Host-adaptation of Francisella tularensis alters the bacterium's surface-carbohydrates to hinder effectors of innate and adaptive immunity. PLoS ONE, 6(7): e22335.
Book Chapters & Reviews
Zarrella, T. M., & Bai, G. (2025) The bacterial second messenger cyclic di-AMP and inflammation. In: Wang, YX. (eds) Inflammation. Book Chapter. Springer, Cham. doi: https://doi.org/10.1007/978-3-031-55254-0_1-1
Zarrella, T. M., & Bai, G. (2021) The many roles of the bacterial second messenger cyclic di-AMP in adapting to stress cues. Minireview. Journal of Bacteriology. doi: 10.1128/JB.00348-20.
Zarrella, T. M., & Bai, G. (2020) Cyclic di-AMP signaling in Streptococcus pneumoniae. In Microbial cyclic di-nucleotide signaling (Eds. Chou, S., Guiliani, N., Lee, V., and Römling, U.). Chapter 27. Springer Nature Switzerland AG.
Patents
Chimeric dual TLR2-CR2(n) fusion ligand. (2016) Patent #9475853. Inventors: K. R. O. Hazlett, E. J. Gosselin, T. J. Sellati, and T. M. Zarrella